About Human Research Protections (HRP) and the Institutional Review Board (IRB)
HRP is responsible for managing the University's human research protections program. The HRP staff provides administrative support to UCI's four Institutional Review Boards (IRB). Research involving human subjects must undergo review by the Institutional Review Board (IRB). The IRB is charged with the responsibility of reviewing human subjects research and ensuring compliance with federal regulations, state laws, and UC/UCI policies. The primary role of the IRB is to protect the safety and welfare of human subjects. UCI has four IRB committees: two review biomedical research (IRBs “A” and “B”), the third (IRB “C”) reviews social/behavioral research and the fourth (IRB “E”) reviews matters of alleged noncompliance. Each committee is composed of physicians, scientists, non-scientists, and community members with varying backgrounds to promote complete and adequate review of the research activities conducted at UCI. Members are appointed by the Vice Chancellor for Research who is the UCI Official responsible for the human research protections program. In addition to working with the IRBs, HRP staff also work directly with investigators and their administrative staff to facilitate submission of the required IRB documentation.
HRP also has an Education and Quality Improvement Program (EQUIP) that provides education, training and quality improvement reviews to ensure compliance with federal and state regulations as well as UC/UCI policies. In addition, EQUIP is responsible for evaluating, tracking and monitoring the effectiveness of the UCI HRP to ensure the rights and welfare of human subjects and compliance with applicable laws.