UC Irvine scientists uncover cellular mechanism behind muscle repair

Irvine, Calif., Feb. 27, 2026 — Scientists at the University of California, Irvine’s School of Pharmacy & Pharmaceutical Sciences have discovered how muscle stem cells “flip a switch” to rebuild damaged muscle – a finding that could help address muscle loss linked to aging, injury and widely used weight-loss medications. The study, published this week in Nature Metabolism,…

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A laser focus on melanoma

A laser focus on melanoma

When Mihaela Balu was interviewing for a postdoctoral position nearly two decades ago, she would describe the kind of training she was looking for, and nearly everyone she talked to nationwide said, “You should go to Beckman Laser Institute & Medical Clinic.” Fortunately for UC Irvine, she did. Now an associate professor of dermatology and…

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UC Irvine-led team creates first cell type-specific gene regulatory maps for Alzheimer’s disease

Public health researchers use newly developed data analysis method to build the first cell type-specific gene regulatory maps for Alzheimer’s disease, revealing the genetic mechanisms operating within patients’ brains. The study also identified numerous influential “hub genes” that offer promising new targets for early detection and therapeutic intervention. The National Institute on Aging and the National…

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UC Irvine scientists create powerful enzyme that quickly, accurately synthesizes RNA

UC Irvine scientists used directed evolution to engineer a DNA polymerase that can quickly and accurately produce RNA, overcoming a fundamental limitation of natural enzymes. The new enzyme, C28, synthesizes RNA with high fidelity, supports long sequences, and enables reverse transcription and DNA-RNA amplification, expanding experimental capabilities. The National Science Foundation supported the research. Irvine,…

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Free NASEM Webinar “Openness: Communicating About Research with Animals”

Free NASEM Webinar “Openness: Communicating About Research with Animals”

Institutional Animal Care & Use Committee (IACUC)   Free NASEM Webinar Openness: Communicating About Research with Animals February 18, 2026 12:00-1:00 PM (virtual) The IACUC is sharing a topic of interest with the UCI research community to highlight ongoing discussions regarding research animals. The National Academies for Sciences, Engineering, and Medicine (NASEM) is offering a…

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The ‘forever chemical’ detective

They’re called “forever chemicals” for a reason. Per- and polyfluoroalkyl substances are a group of synthetic compounds that don’t break down easily in the environment – or in our bodies. Used for decades in products like nonstick cookware, stain-resistant carpeting, waterproof clothing and firefighting foam, PFAS have become a global concern because of their widespread…

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Sleep disruption damages gut’s self-repair ability via stress signals from brain

Chronic sleep disruption triggers oxidative stress in intestinal stem cells and impairs the gut’s ability to repair itself. The study maps a previously unknown brain-to-gut communication relay. Findings suggest potential therapeutic strategies to protect or restore gut health. Irvine, Calif., Feb. 5, 2026 — Chronic sleep disruption doesn’t just leave people tired and irritable. It…

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National health research dialogue comes into focus at UC Irvine

National health research dialogue comes into focus at UC Irvine

When national health research leaders gather on a university campus, it reflects more than a visit. It affirms a shared commitment to engaging directly with the environments where discovery, data and care intersect. That commitment was evident on Wednesday, Jan. 14, as National Institutes of Health director Dr. Jay Bhattacharya returned to California for just…

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Beall Applied Innovation hosts event highlighting O.C.’s ‘innovation ecosystem’

“Innovation” was the word of the day at an event featuring campus, business and national leaders in the robust areas of entrepreneurship and intellectual property on Jan. 29 at UC Irvine’s Beall Applied Innovation. “Orange County Innovation Ecosystem: How Strong Patent Protections Enable Our Country to Thrive” was created by the Orange County Business Council,…

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