Stealth tactic makes chemotherapy smarter

Research team designed an experimental prodrug that delivers its toxic, cancer-killing payload inside cells with high immunoproteasome activity, which occurs with certain cancers. Healthy cells are largely unaffected by the masked drug, which is inactive until it enters a cancer cell. In a preclinical model of small cell lung cancer, the treatment significantly reduced tumor…

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​UC Irvine receives $4.2 million NIH award to continue All of Us enrollment

Irvine, Calif. Sept. 16, 2026 — The University of California, Irvine has received a$4.2 million award from the National Institutes of Health to continue enrollment in the All of Us Research Program and to support the study of cardiometabolic health in populations underrepresented in biomedical research. This initiative represents a collaborative NIH effort supported by…

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The car in your garage can power your house

The car in your garage can power your house

Vehicle-to-home charging lets people power their homes when needed with energy stored in batteries in their V2H-enabled, plug-in electric vehicles. V2H is becoming more common thanks to efforts by UC Irvine engineers and external partners such as KB Home, Kia Corp. and EV charging technology developer Wallbox, who have been working together to address structural,…

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If you name it, you can tame it

A 2022 study by the U.S. Centers for Disease Control and Prevention revealed that 67.7% of adults who smoked said they wanted to quit smoking, and 53.5% said they had tried to quit in the past year. Yet less than one in 10 adults who smoke cigarettes succeed in quitting each year. Research led by…

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The energy UC Irvine never used

The energy UC Irvine never used

Not much at UC Irvine looks the way it did in 1994. The buildings have changed, and many have been added. Computers that once occupied specialized rooms are now carried in backpacks, while research equipment has become more sophisticated and, in many cases, more energy-intensive. The ways students learn, faculty teach and researchers work bear…

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UC Irvine selected as new home of UC Global Health Institute

UC Global Health Institute move to UC Irvine expands research partnerships and advances health equity to improve lives in California and around the world. It further establishes the Joe C. Wen School of Population & Public Health as a world-class leader in public health research, education and innovation. The UC Global Health Institute will continue…

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Padilla visits UC Irvine to spotlight research and innovation

U.S. Sen. Alex Padilla visited UC Irvine on Sept. 8 to learn how university research is improving health, driving innovation and advancing the search for new treatments for Alzheimer’s disease and other forms of dementia. Padilla met with campus leaders for presentations on UC Irvine’s research portfolio, UCI Health, Beall Applied Innovation and UCI MIND…

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Stopping chronic pain before it starts

Researchers discovered that after an injury, support cells are temporarily rewired to trigger nerve cells to produce sticky beta-amyloid protein fragments best known for their role in Alzheimer’s disease. In mice, blocking this process shortly after injury prevented pain from becoming persistent without dulling the initial, acute pain response. The findings, published in Science Translational…

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New data infrastructure award to help scientific communities build domain-specific platforms for collaborative data science and AI

Irvine, Calif., Aug. 27, 2026 — Researchers at UC Irvine, UCLA and the University of Michigan have received nearly $9 million from the U.S. National Science Foundation to establish a new data infrastructure capability that will help scientific communities across the nation use advanced data science and artificial intelligence tools. The award, called NSF BRIDGE…

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