Activities that require UCI hSCRO review: Per UCI hSCRO Policy, hSCRO review and approval is required prior to initiating the following activities: Generation of new lines of human pluripotent* stem cells from whatever source and by whatever means. Use or derivation of the following materials: human gametes human embryos / blastocysts human induced pluripotent stem…

How to Submit NEW Protocols for hSCRO Review Have questions about your hSCRO protocol? Visit our Office Hours! Ready to submit to ZOT hSCRO? Click here! Review the ZOT hSCRO User Guide! Click here! Who can submit hSCRO Protocols at UCI / UCSB? Please review the HRPP “Principal Investigator (PI) Eligibility” webpage. UCI has a…

Modifications to hSCRO Approved Research Once a human stem cell protocol has received hSCRO approval, any subsequent changes to the study must be reviewed and approved by the hSCRO Committee prior to implementation. Exception: updates can be made at the time of renewal when generation of new cell lines is ongoing from previously verified material…

Use of Human Fetal Tissue in research All use of human fetal tissue at UCI or UCSB will require hSCRO review.  Per CIRM regulations: [100020] – Definitions [100085] – Use of Fetal Tissue – Review the linked document for detailed guidance on required documentation including: Statement signed by donor (can be in the form of a…

Additional Guidelines and Regulations  Guidelines for Research on Human Embryonic Stem CellsThe National Academies recommended guidelines for research involving human embryonic stem cells, and urges all institutions conducting such research to establish oversight committees to ensure that the new guidelines will be followed. The guidelines are intended to enhance the integrity of privately funded human…

Overview All stem cell activities require hSCRO review before they are initiated. Activities involving vertebrate animals will require UCI IACUC approval. Activities involving potentially hazardous biological agents including but not limited to infectious agents, human and non-human primate materials (including established cell lines), CDC select agents, recombinant DNA and studies involving human gene transfer will…