Submission of IACUC Modification Requests

Significant changes include any changes that

• Involve or affect the animals
• May impact personnel safety
• Alter procedures, experimental design or scope of work

Follow the below steps to start and submit a mod in RMS

1. Create a new modification in RMS, by clicking the Modification button
2. To enable editing, click the Check-Out button
3. Fill out the Modification Tab in RMS, indicating all proposed changes

AUP form fields

4. Revise the corresponding Protocol Tabs in RMS, incorporating the proposed changes
5. Once ready to submit, click the Submit to IACUC button

Additional Information & Tips

• For technical assistance, contact era@research.uci.edu.
• For more information about modifications, refer to the IACUC Policy on Modifications
• It is strongly recommended submitting your modifications as early as possible, in case it may need to go to full committee review.
• Level of review for a modification is determined by the IACUC office. If you have an urgency, please contact us to discuss.
• Designated Member Review:  Allow a minimum of 2 weeks for review (turnaround time will vary)
• Full Committee Review: Submissions: must be received by the deadline dates to be considered for the next meeting agenda.NOTE:  Submitting by the deadline date does not guarantee making it onto the agenda! Agenda capacity is determined on a first-come first-served basis, dependent on the number of submissions our office has already received and the number of scientific reviewers available.
• For guidance about hazards, please contact EH&S at (949) 824-2041

Administrative changes include changes to

• Non-key personnel -- Key personnel are the PI, and Faculty Sponsor
• Lab areas where animals are used that are outside of the ULAR-managed vivarium
• Funding

Follow the below steps to start and submit a mod in RMS

1. Create a new modification in RMS, by clicking the Modification button
2. To enable editing, click the Check-Out button
3. Fill out the Modification Tab, indicating all proposed change
4. Once ready, submit by clicking on the Submit to IACUC button

Additional Information & Tips

• For technical assistance, contact era@research.uci.edu.
• Administrative modifications include changes to:
  • Non-key personnel
  • Locations outside the vivarium where animals are used (lab areas)
  • Funding
• Addition of new personnel requires completion of training requirements:
  • CITI Training
    • Log into CITI and complete the required training, along with any other protocol-specific modules.For guides on how to enroll, contact the IACUC Office at IACUC@uci.edu
  • LAOHP Questionnaire
    • Enroll or opt out of the Laboratory Animal Occupational Health Program (LAOHP) Questionnaire
      (instructions on how to opt out are within the questionnaire)
    • This questionnaire needs to be updated annually
    • For questions about LAOHP, contact EH&S at (949)824-3757

  It is recommended to have these completed prior to submission!

• For more information about modifications, refer to the IACUC Policy on Modifications

Notes about Personnel Additions

• Personnel MAY NOT handle live animals until they have been officially added to the protocol
• Requests for vivaria access may require completion of additional species-specifc CITI training modules - ULAR will let you know which additional ones you need to take
• For questions about UCInetIDs, please visit the OIT UCInetIDs website or contact OIT at (949) 824-2222