Submission of IACUC Annual Review


Follow below steps to complete and submit the Annual Review:

  1. From the email, click on the direct protocol link - This will take you directly to your protocol.
    (or login to RMS website, the Document Status will be in "Annual Review")
  2. Enable editing by clicking the Check-out button.
  3. In the protocol, complete the Annual Review Tab ONLY.(Other protocol tabs in RMS do not need to be updated at this time.)
  4. Once ready to submit, click the Submit to IACUC button.


For Offsite Registrations, contact for annual review instructions.

RMS only allows one modification submission
at a time

If you need to make significant changes and personnel additions/deletions, please include ALL proposed changes together into the modification request.

Email if you need personnel changes to be expedited.

Additional Information & Tips

  • Annual Reviews are due on the anniversary date of when the current protocol cycle was initially approved.**If you use USDA-covered species = Submit 30 days before your anniversary date.
  • (see additional notes below)
  • Researchers are required to self-report all other animals (not purchased through ULAR) - This includes:
    • Animals produced in UCI breeding colonies
    • Offspring of animals purchased as pregnant dams or dams-with-litter
    • Exotic animals (e.g., reptiles caught in the wild or procured from non-traditionalsources)See guidance about Reporting Animal Numbers for Annual Reviews
  • Modifications involving the animals or experimental/procedural changes CANNOT be made when a protocol is in "Annual Review status" - Please complete the Annual Review first, then contact to request for expedited processing. We will turn it around for you to start a new modification submission.
  • If additional clarifications about the annual review are needed, the PI will be contacted via email.


For protocols that use USDA-covered species, submit your annual reviews at least 30 days before your protocol's anniversary date (the date when the current cycle was first approved).

Annual reviews involving USDA-covered species will go to Full Committee Review for discussion at the next convened meeting.

If you do not submit your annual review by the anniversary date, animal ordering will be placed on hold until your annual review submission is received.

USDA-covered species include:

  • Peromyscus Mouse
  • Hamster
  • Guinea Pig
  • Rabbit
  • Cat
  • Sheep
  • Pig
  • ...and other warm-blooded vertebrate animals! (EXCLUDING mice and rats purposely bred for research)

Unsure if you use USDA-covered species? Email for assistance.