Submission of New Applications & 3-Year Renewals of IACUC Protocols
Start the Process
Note
Only 2 roles in RMS have permissions to create, edit, and submit new applications or 3-year renewals to the IACUC:
"Principal Investigator" and “Co-Investigator/Senior Researcher”
If you do not have either of these roles, email IACUC@uci.edu for assistance
Preparing your submission:
- See the RMS User Guide for guidance on how to use RMS. For technical assistance, contact ERA Support Desk.
- See Protocol Writing Tips & Guidance for suggestions and best practices to help improve your chances of obtaining IACUC approval.
- IMPORTANT: The Lead Researcher (LR) must complete required CITI training, or this may delay application processing.
- Submit your submission as early as possible. Submissions must be received by the deadline date and time to be considered as an item on the full committee meeting agenda.
- If you have questions about the use of hazardous agents, contact EHS at safety@uci.edu or (949) 824-6200.
- For three-year renewals, to use your existing protocol as a base draft for the three-year renewal application, please email your request to IACUC@uci.edu.
Pre-review Process:
Once submitted, your protocol will undergo a rigorous pre-review by IACUC committee members, administrative, veterinary, and EHS staff.
If additional clarifications are needed, a pre-review summary will be sent to the LR to allow for the opportunity to clarify, revise, and respond to comments prior to the date of the IACUC full committee meeting.
See Responding to Pre-review for more info
3-year Renewal Tips
For on-going experiments: Refer to your old (or current) protocol to copy/paste relevant information into the appropriate RMS sections/tabs.
**You will receive a confirmation email, stating whether or not your submission made it onto the agenda for the next full committee meeting.
Important Reminders
- For 3-year renewals, the renewal application must be reviewed and approved before the current protocol cycle expires to avoid a lapse in approval. If the current protocol expires before the renewal is approved, all live animal work must cease and may not resume until approval from the IACUC has been obtained for the new cycle. Any remaining animals housed under the expired protocol will be transferred to the ULAR Holding Protocol. Animals on the holding protocol are off-limits to investigators and no experimental manipulations or observations are allowed. Refer to the Holding Protocol Policy for more information.
- All laboratory personnel with live-animal contact must complete the Laboratory Animal Occupational Health Program (LAOHP) Questionnaire (this needs to be updated annually). Refer to the LAOHP for more information. For questions regarding the LAOHP, contact EHS at occhlth@uci.edu or (949) 824-6200.
- Other additional regulatory committee reviews may be required for your study, if you use any of the following:
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- Biohazardous Agents (e.g., infectious agents, human/primate biological materials, recombinant DNA, etc.) may require IBC review – Contact IBC@uci.edu.
- Human Stem Cells (e.g., embryonic, induced adult hSCs, etc.) may require hSCRO review – Contact hSCRO@uci.edu.
- Radioactive agents or instruments (e.g., iodinated proteins, irradiator, X-rays, etc.) may require RSC review – contact radsafety@uci.edu.
- Human cells (e.g., patient cancer cells, blood, tissues, etc.) may require IRB review – Contact IRB@uci.edu.