Modifying an Approved AUP
Who Can Modify?
Note: Only 2 roles have permissions to create, edit, and submit modifications: "Principal Investigator" and “Co-Investigator/Senior Researcher”
If you do not have either of these roles, email IACUC@uci.edu for assistance
Submitting a Modification
Before starting a modification, identify where your protocol details are in RMS. This will determine what your next steps are.
- Complete the Modification Tab in RMS (Step 1)
- Incorporate all proposed changes into the relevant Protocol Tabs
- Go into the protocol, click the Modification button to create a new Modification version.
A comment window will pop up - You may leave blank or enter optional notes, then click the 
button.
- The Modification Tab will now appear at the top, and the protocol status/version will indicate "Modification".
- Enable editing by clicking the Check-out button.
- Fill out the Modification Tab form - This acts like a cover letter to all proposed changes in your modification request.
Mark the applicable checkboxes and answer any required subsequent questions..
- Incorporate your proposed changes into the protocol...
Tip: Guidance on which tabs/sections to update can be found by hovering your cursor over the 
purple info icon
(Refer to guidance about specific protocol tabs from the RMS User Guide)
SAVE your work periodically - Click the 
button.
Once you're ready to submit, click the Submit to IACUC button.
A comment window will pop up again - You may leave blank or enter optional notes about your submission, then click the button to complete submission.
Once your modification is sent out for review, additional clarifications may be needed - Keep an eye on your emails!
Personnel Changes
After completing Steps 1-4 above, go to the Personnel Tab to add/remove users.
If you cannot find a user to add, they do not yet have a RMS user profile - Fill out the Mod Tab to "Add Personnel", providing their UCInetID. Once your mod is submitted, an IACUC admin will process the personnel changes.