About Human Research Protections (HRP)
HRP manages UCI's human research protections program by providing administrative support to its Institutional Review Boards (IRB). The IRB is responsible for protecting the safety and welfare of human subjects. Federal regulations, state laws, and UC and UCI policy require IRB review and approval before researchers may conduct research involving human subjects.
HRP staff work directly with investigators and their administrative staff to assist them with understanding IRB requirements and the process for submitting research protocols to the IRB. HRP also runs the Education and Quality Improvement Program (EQUIP) to educate and train researchers and conduct quality improvement reviews.
Are you thinking about participating in human subject research?
IRB Member Rosters
Access our most recent rosters here.
General Information Often Requested by Study Sponsors
Answers to common requests from study sponsors (e.g. FWA and IRB reg. numbers).
HRP Fast Facts
Quick Answers to Common Questions
CARE-Q Certified
UCI was the pilot site for Care-Q. Â Re-accreditation was renewed in 2023.
Kuali Research Protocols (KRP)
UCI's IRB, sIRB and hSCRO submission and management system.
Limited Submissions + Data MigrationÂ
ZOT IRB will launch on September 15, 2025. Beginning August 4, 2025 the UCI IRB and hSCRO will allow limited submissions only. This will allow additional time for HRP to clear their review queue, train on the new system and, importantly, complete the data migration process.
In order to transition to Huron IRB, the HRP must migrate current data in Kuali Research Protocols (KRP). Please note that unsubmitted drafts and submitted transactions in KRP that remain unapproved by the IRB will NOT transfer to ZOT IRB – they will be discarded.
Please work closely with the HRP to process out all transactions prior to the transfer. For more information including what submissions will be allowed in KRP from August 4 – September 14 (and how to submit), CLICK BELOW.
Tools and Resources
 *Available on campus or Cisco VPN; UCINetID requiredÂ