How to Submit Protocols to the UCI hSCRO

The following three documents are required to request review of a study by the UCI hSCRO.

1. Protocol Narrative

  • Each submission prepared for hSCRO review must include a Protocol Narrative.
  • Please complete each section as prompted in the instruction box.
  • For sections such as the background information, aims, outcome variables, methods and procedures, the investigators are encouraged to provide information listed in grant applications to ensure that the Committee has sufficient and complete information for review.

2. Cell Tracking Table

  • Material:
    Each cell line or material such as human embryonic cell line, human induced pluripotent stem cell line, embryo, oocyte, fetal tissue or fetal-tissue derived cell lines, neural stem cells that will be used in animals must be listed individually on a separate row.Non-human cell lines, cell lines that are not pluripotent (except for fetal-tissue origin multipotent stem cells or neural progenitors cells to be used in vivo) will NOT need to be listed in the Cell Tracking Table.Somatic cells (fibroblasts) that have not yet been used to create pluripotent lines should NOT be included in the Cell Tracking Table. Instead, somatic cells which are stored for later use would be listed in Section 3 of the narrative.

Submitting a Continuation Application

Please submit your continuation application to the hSCRO Administrator via email at hSCRO@research.uci.edu. The application should be signed by the lead researcher then scanned and emailed to hSCRO@research.uci.edu. 

Alternatively, in lieu of signing the application, the lead researcher can certify in the submission email that

"I certify that the information contained herein is true and accurate to the best of my knowledge. I confirm this application for continuing review accurately reflects the current research activities associated with this protocol. I understand that if any changes need to be made, I should obtain approval for the change(s) via modification request prior to seeking continuing review or hold proposed changes until after continuing approval has been granted". 

  • Cell Line Name / ID:
    Each cell line must be listed with either their name or ID. If multiple cell lines are made from the same source (for example, if multiple iPSCs are made from the sample fibroblast line, each iPSCs line should be listed separately).
  • Supplier:
    List the name or the individual or institution that will directly supply the material. Examples are provided in the table.
  • Provenance / Source Information:
    List the specific Cell Registry, UCI or non-UCI IRB-approved protocol number under which the source material was collected or the Company and the Catalog number for somatic cells used to generate iPSCs,
  • Registry Number:
    For human embryonic stem cells only, list the specific NIH, CIRM, UK Stem Cell Registry number.

3. Application for hSCRO Review 

The Application for hSCRO review must be completed for protocol submissions to the UCI hSCRO. The guidance below will assist investigators with completion of the hSCRO Application and Protocol Narrative.

  • Study Funding:
    Investigators should provide information related to the source of funding for their project.
  • Other UCI Committee approvals:
    Indicate all applicable committee reviews that are required for this research. If a protocol has already been approved specify the protocol number.
  • Location and Storage of Cells:
    Indicate the location (building and room number) for research activities (cell culture, animal experiments) and storage of materials.
  • Departmental Approval:
    The Department/ Organized Research Unit (ORU) Chair/Director’s or designee’s assurance statement must be signed on the application.
  • Lead Researcher Certification:
    Lead Researcher/Principal Investigator must review the list of responsibilities which must be met to ensure adequate conduct and oversight of the study.

The application must be signed and dated by the Lead Researcher/Principal Investigator.

Questions about Submitting to the UCI hSCRO

Feel free to contact hSCRO@research.uci.edu if you have any questions about the hSCRO review process or how to complete the hSCRO application.